Description

Transferrin is the major iron-transferring protein in plasma, providing the iron needed for cell internalization and cellular metabolism. The study found that all cell growth is inseparable from transferrin. Not only does it maintain normal cellular metabolism, it depends on iron in the form of biological activity, iron is also a cofactor for some enzymes, such as RNA polymerase, DNA synthetase. It is also an important part of hemoglobin.
Transferrin is a plasma glycoprotein isolated from plasma. Bovine transferrin exists in two molecular forms with molecular weights of 74KD and 78KD, respectively. Each transferrin molecule can bind two molecules of iron ions through the C-terminal and N-terminal structural sites, so transferrin exists in three forms: deferred iron (without binding to iron ions), saturated iron (with two molecules of iron ions) And partially saturated, under physiological conditions, only 1/3 of the transferrin molecules are saturated with iron.
Transferrin is essential for the growth of most cell lines in serum-free media, and studies have shown that ferroferrin in saturated iron form is the most effective form for promoting cell growth. For hybridomas, adherent cells and suspension cell lines, the concentration of transferrin in the medium should be maintained at 0.5-100 μg/ml during cell culture. For the different cell lines, you need to choose the most suitable concentration.

Specification:1g