Description

Fibroblast activation protein α, also known as seprase protein or melanoma membrane combined with gelatinase, is a 170kDa protein encoded by FAP gene (2q23) in human body. It is a homodimer and belongs to the membrane of serine protease family. Gelatinase. It is selectively expressed in the reaction matrix of epithelial cancer fibroblasts, the granulation tissue of the healing wound, and the malignant cells of bone and soft tissue sarcoma. This protein is thought to be involved in fibroblast growth, epithelial-mesenchymal interaction control, tissue repair, and epithelial carcinogenesis during development. FAP, also known as seprase, belongs to the SC protease family and is a subfamily of the S9B proline oligopeptidase. Other members of the S9B subfamily also have DPPIV, DPP8 and DPP9. FAP has a high correlation with DPPIV, which is about 50% identical amino acids. FAP is a catalytically active dimer of 170 kDa size with both dipeptidase and gelatinase enzyme activities. Gelatinase activity requires the presence of glycine at the P2 position.

Dosage form: liquid
Ingredients: Recombinant human fibroblast activation protein is dissolved in PBS solution (pH 7.4)
Protein concentration: 1-2mg/ml
Shipping conditions: low temperature ice pack
Source: A DNA sequence encoding the human FAP (NM_004460.3) extracellular region and the affinity tag sequence in HEK293 cell fusion protein
Molecular weight: about 90 kDa (SDS-PAGE detection)
Purity: > 90% (SDS-PAGE detection)
Storage conditions: 4 °C Regular use, -20 °C long-term preservation, avoid repeated freezing and thawing.

specification:1mg

NOT:It is strictly forbidden to be used in human experiments and not for clinical treatment.